Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson’s Disease

Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson’s Disease

The degeneration of nigral dopaminergic neurons is considered the hallmark of Parkinson’s disease (PD), and it is triggered by different factors, including mitochondrial dysfunction, Lewy body accumulation, neuroinflammation, excitotoxicity and metal accumulation. Despite the extensive literature de...

Full description

Bibliographic Details
Main Authors: Ezia Guatteo, Nicola Berretta, Vincenzo Monda, Ada Ledonne, Nicola Biagio Mercuri
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
PD toxicity
electrophysiological modifications
firing
excitability
substantia nigra
dopamine
Online Access:https://www.mdpi.com/1422-0067/23/9/4508

Internet

https://www.mdpi.com/1422-0067/23/9/4508

Similar Items