Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy

Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy

We evaluated whether inhibiting sterile alpha and (Toll/interleukin receptor (TIR)) motif-containing 1 (SARM1) activity protects retinal ganglion cells (RGCs) following ischemic axonopathy (rodent nonarteritic anterior ischemic optic neuropathy: rNAION) by itself and combined with ciliary neurotroph...

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Bibliographic Details
Main Authors: Yan Guo, Zara Mehrabian, Jeffrey Milbrandt, Aaron DiAntonio, Steven L. Bernstein
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
optic nerve
nonarteritic anterior ischemic optic neuropathy (NAION)
sterile alpha and (toll/interleukin receptor (TIR)) motif-containing 1 (SARM1)
rodent
ischemia
axonopathy
Online Access:https://www.mdpi.com/2073-4409/13/3/202

Internet

https://www.mdpi.com/2073-4409/13/3/202

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