GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss

Summary: The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current experiments in rats investigate whether GDF15 induces an aversive visceral malaise-based state that mediates its acute anorectic effec...

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Bibliographic Details
Main Authors: Tito Borner, Hallie S. Wald, Misgana Y. Ghidewon, Bei Zhang, Zhidan Wu, Bart C. De Jonghe, Danna Breen, Harvey J. Grill
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720304435