Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides

Heparan sulfates (HS) contain functionally relevant structural motifs, but determining their monosaccharide sequence remains challenging. Here, the authors develop an ion mobility mass spectrometry-based method that allows unambiguous characterization of HS sequences and structure-activity relations...

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Bibliographic Details
Main Authors: Rebecca L. Miller, Scott E. Guimond, Ralf Schwörer, Olga V. Zubkova, Peter C. Tyler, Yongmei Xu, Jian Liu, Pradeep Chopra, Geert-Jan Boons, Márkó Grabarics, Christian Manz, Johanna Hofmann, Niclas G. Karlsson, Jeremy E. Turnbull, Weston B. Struwe, Kevin Pagel
Format: Article
Language:English
Published: Nature Portfolio 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15284-y

Internet

https://doi.org/10.1038/s41467-020-15284-y

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