Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

Abstract Background Delayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which can bring great distress to patients. In diabetic patients, macrophages accumulate around skin wounds and produce NLRP3 (NOD-, LRR-, and pyrin domain-con...

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Bibliographic Details
Main Authors: Yiming Wang, Lin Jing, Xiao Lei, Zhen Ma, Bei Li, Yuanyuan Shi, Wuyang Zhang, Yuan Li, Hongzhi Zhou, Kaijin Hu, Yang Xue, Yan Jin
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Stem Cell Research & Therapy
Subjects:
Diabetic cutaneous wound
Apoptotic extracellular vesicles
Pyroptosis
Oxidative stress
Cell death regulation
Online Access:https://doi.org/10.1186/s13287-023-03490-6

Internet

https://doi.org/10.1186/s13287-023-03490-6

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