Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice

Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice

Dihydromyricetin is a natural bioactive flavonoid with unique GABA<sub>A</sub> receptor activity with a putative mechanism of action to reduce the intoxication effects of ethanol. Although dihydromyricetin’s poor oral bioavailability limits clinical utility, the promise of this mechanism...

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Bibliographic Details
Main Authors: Eileen Carry, Dushyant Kshatriya, Joshua Silva, Daryl L. Davies, Bo Yuan, Qingli Wu, Harna Patel, Elizabeth R. Park, John Gilleran, Lihong Hao, Jacques Roberge, Nicholas T. Bello, James E. Simon
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
dihydromyricetin
metabolism
bioavailability
GABA<sub>A</sub> receptors
acute alcohol intoxication
alcohol use disorder
Online Access:https://www.mdpi.com/1422-0067/22/14/7460

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https://www.mdpi.com/1422-0067/22/14/7460

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