A Hemagglutinin Stem Vaccine Designed Rationally by AlphaFold2 Confers Broad Protection against Influenza B Infection

A Hemagglutinin Stem Vaccine Designed Rationally by AlphaFold2 Confers Broad Protection against Influenza B Infection

Two lineages of influenza B viruses (IBV) co-circulating in human beings have been posing a significant public health burden worldwide. A substantial number of broadly neutralizing antibodies (bnAbs) have been identified targeting conserved epitopes on hemagglutinin (HA) stem domain, posing great in...

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Detalhes bibliográficos
Principais autores: Dian Zeng, Jiabao Xin, Kunyu Yang, Shuxin Guo, Qian Wang, Ying Gao, Huiqing Chen, Jiaqi Ge, Zhen Lu, Limin Zhang, Junyu Chen, Yixin Chen, Ningshao Xia
Formato: Artigo
Idioma:English
Publicado em: MDPI AG 2022-06-01
coleção:Viruses
Assuntos:
influenza B viruses (IBV)
stem hemagglutinin (HA)
vaccine design
structure prediction
AlphaFold2
broad protection
Acesso em linha:https://www.mdpi.com/1999-4915/14/6/1305

Internet

https://www.mdpi.com/1999-4915/14/6/1305

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