IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells.

IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells.

Earlier, we have shown that GM-CSF-exposed CD8α- DCs that express low levels of pro-inflammatory cytokines IL-12 and IL-1β can induce Foxp3+ Tregs leading to suppression of autoimmunity. Here, we examined the differential effects of IL-12 and IL-1β on Foxp3 expression in T cells when activated in th...

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Bibliographic Details
Main Authors: Balaji B Ganesh, Palash Bhattacharya, Anupama Gopisetty, Jianrong Sheng, Chenthamarakshan Vasu, Bellur S Prabhakar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3136935?pdf=render

Internet

http://europepmc.org/articles/PMC3136935?pdf=render

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