Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents
The Pd/C–PPh3 catalyst system facilitated the C–C bond forming reaction between 3-iodo-1-methyl-1H-indole and various terminal alkenes under ultrasound irradiation. The present ultrasound assisted Mizoroki–Heck coupling afforded a number of 3-vinyl indole derivatives in good to acceptable yields. Tw...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535216000277 |
| _version_ | 1811215571338919936 |
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| author | S. Bhavani Mohd Ashraf Ashfaq D. Rambabu M.V. Basaveswara Rao Manojit Pal |
| author_facet | S. Bhavani Mohd Ashraf Ashfaq D. Rambabu M.V. Basaveswara Rao Manojit Pal |
| author_sort | S. Bhavani |
| collection | DOAJ |
| description | The Pd/C–PPh3 catalyst system facilitated the C–C bond forming reaction between 3-iodo-1-methyl-1H-indole and various terminal alkenes under ultrasound irradiation. The present ultrasound assisted Mizoroki–Heck coupling afforded a number of 3-vinyl indole derivatives in good to acceptable yields. Two of these indole derivatives showed cytotoxic activities against breast cancer cell lines. Keywords: Indole, Alkenes, Pd/C, Ultrasound, Cytotoxicity |
| first_indexed | 2024-04-12T06:24:47Z |
| format | Article |
| id | doaj.art-7724fdacc51640479b7466c0e3efac78 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-12T06:24:47Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-7724fdacc51640479b7466c0e3efac782022-12-22T03:44:11ZengElsevierArabian Journal of Chemistry1878-53522019-12-0112838363846Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agentsS. Bhavani0Mohd Ashraf Ashfaq1D. Rambabu2M.V. Basaveswara Rao3Manojit Pal4Department of Chemistry, K.L. University, Vaddeswaram, Guntur 522502, Andhra Pradesh, IndiaDr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, IndiaDepartment of Chemistry and the National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be’er-Sheva 84105, IsraelDepartment of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India; Corresponding authors. Tel.: +91 40 6657 1500.Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India; Corresponding authors. Tel.: +91 40 6657 1500.The Pd/C–PPh3 catalyst system facilitated the C–C bond forming reaction between 3-iodo-1-methyl-1H-indole and various terminal alkenes under ultrasound irradiation. The present ultrasound assisted Mizoroki–Heck coupling afforded a number of 3-vinyl indole derivatives in good to acceptable yields. Two of these indole derivatives showed cytotoxic activities against breast cancer cell lines. Keywords: Indole, Alkenes, Pd/C, Ultrasound, Cytotoxicityhttp://www.sciencedirect.com/science/article/pii/S1878535216000277 |
| spellingShingle | S. Bhavani Mohd Ashraf Ashfaq D. Rambabu M.V. Basaveswara Rao Manojit Pal Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents Arabian Journal of Chemistry |
| title | Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents |
| title_full | Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents |
| title_fullStr | Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents |
| title_full_unstemmed | Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents |
| title_short | Ultrasound assisted Mizoroki–Heck reaction catalyzed by Pd/C: Synthesis of 3-vinyl indoles as potential cytotoxic agents |
| title_sort | ultrasound assisted mizoroki heck reaction catalyzed by pd c synthesis of 3 vinyl indoles as potential cytotoxic agents |
| url | http://www.sciencedirect.com/science/article/pii/S1878535216000277 |
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