Pericentromeric Non-Coding DNA Transcription Is Associated with Niche Impairment in Patients with Ineffective or Partially Effective Multiple Myeloma Treatment

Pericentromeric Non-Coding DNA Transcription Is Associated with Niche Impairment in Patients with Ineffective or Partially Effective Multiple Myeloma Treatment

Mesenchymal stromal cells (MSC) ‘educated’ by tumor cells are an essential component of the multiple myeloma (MM) tumor microenvironment (TME) involved in tumor progression. Transcription of tandemly repeated (TR) non-coding DNA is often activated in many tumors and is required for tumor progression...

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Bibliographic Details
Main Authors: Natella I. Enukashvily, Natalia Semenova, Anna V. Chubar, Dmitry I. Ostromyshenskii, Ekaterina A. Gushcha, Sergei Gritsaev, Stanislav S. Bessmeltsev, Viktor I. Rugal, Egor M. Prikhodko, Ivan Kostroma, Anastasia Zherniakova, Anastasia V. Kotova, Liubov A. Belik, Alexander Shumeev, Irina I. Maslennikova, Dmitry I. Ivolgin
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
multiple myeloma
mesenchymal stromal cells
microvessels
tumor microenvironment
long non-coding RNA
human satellite 3
Online Access:https://www.mdpi.com/1422-0067/23/6/3359

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https://www.mdpi.com/1422-0067/23/6/3359

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