Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

Activated microglia and infiltrating lymphocytes are neuropathological hallmarks of amyotrophic lateral sclerosis (ALS), a fatal motoneuron disease. Although both cell types play pivotal roles in the ALS pathogenic process, the interactions between microglia and lymphocytes, specifically regulatory...

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Bibliographic Details
Main Authors: Weihua Zhao, David R. Beers, Bing Liao, Jenny S. Henkel, Stanley H. Appel
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neurobiology of Disease
Subjects:
ALS
T lymphocytes
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002495

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http://www.sciencedirect.com/science/article/pii/S0969996112002495

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