Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease

Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease

Alpha-synuclein (non A4 component of amyloid precursor, SNCA, NM_000345.3) plays a central role in the pathogenesis of Parkinson's disease (PD) and related Lewy body disorders such as Parkinson's disease dementia, Lewy body dementia, and multiple system atrophy. Since its discovery as a di...

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Bibliographic Details
Main Authors: Desiree A. Piper, Danuta Sastre, Birgitt Schüle
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Neuroscience
Subjects:
alpha-synuclein
SNCA
transcriptional regulation
induced pluripotent stem cells
Parkinson's disease
Dementia with Lewy bodies
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00199/full

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http://journal.frontiersin.org/article/10.3389/fnins.2018.00199/full

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