Glycoproteoform Profiles of Individual Patients’ Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode

Glycoproteoform Profiles of Individual Patients’ Plasma Alpha-1-Antichymotrypsin are Unique and Extensively Remodeled Following a Septic Episode

Sepsis and septic shock remain the leading causes of death in intensive care units (ICUs), yet the pathogenesis originating from the inflammatory response during sepsis remains ambiguous. Acute-phase proteins are typically highly glycosylated, and the nature of the glycans have been linked to the in...

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Bibliographic Details
Main Authors: Tomislav Čaval, Yu-Hsien Lin, Meri Varkila, Karli R. Reiding, Marc J. M. Bonten, Olaf L. Cremer, Vojtech Franc, Albert J. R. Heck
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
acute-phase proteins
sepsis-diagnostics
glycoproteomic analysis
alpha-1-antichymotrypsin
acute phase response (APR)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.608466/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.608466/full

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