Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells

Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells

Triple-negative breast cancer (TNBC) is a highly aggressive and metastasizing cancer that has the worst prognosis out of all breast cancer subtypes. The epithelial–mesenchymal transition (EMT) and cancer stem cells (CSCs) have been proposed as important mechanisms underlying TNBC metastasis. CDK9 is...

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Bibliographic Details
Main Authors: Shasha Cheng, Guan-Jun Yang, Wanhe Wang, Dik-Lung Ma, Chung-Hang Leung
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-11-01
Series:Genes and Diseases
Subjects:
Cancer stem cells
CDK9-cyclin T1
Epithelial mesenchymal transition
Protein–protein interaction (PPI)
Triple-negative breast cancer (TNBC)
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304221000866

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http://www.sciencedirect.com/science/article/pii/S2352304221000866

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