Cell-derived Newcastle disease virus variant with two amino acid substitutions near cleavage site of F shows favorable traits as oncolytic virus

Cell-derived Newcastle disease virus variant with two amino acid substitutions near cleavage site of F shows favorable traits as oncolytic virus

Newcastle disease virus (NDV) has shown encouraging effectiveness in in vitro, in vivo, and in early clinical trials as a viro-immunotherapy for pancreatic cancer. Previously, NDV used in clinical trials was produced in embryonated chicken eggs; however, egg-produced viruses are known to be partly n...

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Bibliographic Details
Main Authors: Marco Huberts, J. Fréderique de Graaf, Daphne Groeneveld, Stefan van Nieuwkoop, Ron A.M. Fouchier, Bernadette G. van den Hoogen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
Newcastle disease virus
NDV
viro-immunotherapy
pancreatic cancer
embryonated chicken eggs
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924001577

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http://www.sciencedirect.com/science/article/pii/S2950329924001577

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