Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck

Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck

Under physiological conditions, CD8+ T cells need to recognize low numbers of antigenic pMHC class I complexes in the presence of a surplus of non-stimulatory, self pMHC class I on the surface of the APC. Non-stimulatory pMHC have been shown to enhance CD8+ T cell responses to low amounts of antigen...

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Bibliographic Details
Main Authors: Xiang Zhao, Liang-Zhe Wu, Esther K. Y. Ng, Kerisa W. S. Leow, Qianru Wei, Nicholas R. J. Gascoigne, Joanna Brzostek
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
co-agonism
Lck
T cell receptor
non-stimulatory peptide MHC
T cell signaling
T cell effector functions
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.721722/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.721722/full

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