deMULTIplex2: robust sample demultiplexing for scRNA-seq

deMULTIplex2: robust sample demultiplexing for scRNA-seq

Abstract Sample multiplexing enables pooled analysis during single-cell RNA sequencing workflows, thereby increasing throughput and reducing batch effects. A challenge for all multiplexing techniques is to link sample-specific barcodes with cell-specific barcodes, then demultiplex sample identity po...

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Bibliographic Details
Main Authors: Qin Zhu, Daniel N. Conrad, Zev J. Gartner
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Biology
Subjects:
scRNA-seq
Sample multiplexing
Demultiplex
Generalized linear models
Expectation–maximization
Online Access:https://doi.org/10.1186/s13059-024-03177-y

Internet

https://doi.org/10.1186/s13059-024-03177-y

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