CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

Immunotherapies targeting the “don’t eat me” myeloid checkpoint constituted by CD47 SIRPα interaction have promising clinical potential but are limited by toxicities associated with the destruction of non-tumor cells. These dose-limiting toxicities demonstrate the need to highlight the mechanisms of...

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Bibliographic Details
Main Authors: Françoise Gondois-Rey, Thomas Miller, Vladimir Laletin, Xavier Morelli, Yves Collette, Jacques Nunès, Daniel Olive
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
PMN (polymorphonuclear leucocyte)
SIRPα
NADPH oxidase
CD47 antibody
ADCC (antibody-dependent cellular cytotoxicity)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.899068/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.899068/full

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