Evidence That the Etiology of Congenital Hypopituitarism Has a Major Genetic Component but Is Infrequently Monogenic

Evidence That the Etiology of Congenital Hypopituitarism Has a Major Genetic Component but Is Infrequently Monogenic

PurposeCongenital hypopituitarism usually occurs sporadically. In most patients, the etiology remains unknown.MethodsWe studied 13 children with sporadic congenital hypopituitarism. Children with non-endocrine, non-familial idiopathic short stature (NFSS) (n = 19) served as a control group. Exome se...

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Podrobná bibliografie
Hlavní autoři: Youn Hee Jee, Mariam Gangat, Olga Yeliosof, Adrian G. Temnycky, Selena Vanapruks, Philip Whalen, Evgenia Gourgari, Cortney Bleach, Christine H. Yu, Ian Marshall, Jack A. Yanovski, Kathleen Link, Svetlana Ten, Jeffrey Baron, Sally Radovick
Médium: Článek
Jazyk:English
Vydáno: Frontiers Media S.A. 2021-08-01
Edice:Frontiers in Genetics
Témata:
congenital hypopituitarism
monogenic
digenic
ectopic posterior pituitary gland
combined pituitary hormone deficiencies
On-line přístup:https://www.frontiersin.org/articles/10.3389/fgene.2021.697549/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.697549/full

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