Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells

Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells

First-line drug in the treatment of glioblastoma, the most severe brain cancer, is temozolomide (TMZ), a DNA-methylating agent that induces the critical damage O<sup>6</sup>-methylguanine (O<sup>6</sup>MeG). This lesion is cytotoxic through the generation of mismatch repair-m...

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Bibliographic Details
Main Authors: Lea Beltzig, Christian Schwarzenbach, Petra Leukel, Katrin B. M. Frauenknecht, Clemens Sommer, Alessandro Tancredi, Monika E. Hegi, Markus Christmann, Bernd Kaina
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
temozolomide
apoptosis
senescence
glioblastoma
O<sup>6</sup>-methylguanine
MGMT
Online Access:https://www.mdpi.com/2072-6694/14/9/2233

Internet

https://www.mdpi.com/2072-6694/14/9/2233

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