Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function

Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function

Background: Morphine dependence, a devastating neuropsychiatric condition, may be closely associated with gut microbiota dysbiosis. Ginsenoside Rg1 (Rg1), an active ingredient extracted from the roots of Panax ginseng C.A. Meyer, has potential health-promoting effects on the nervous system. However,...

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Bibliographic Details
Main Authors: Zhijie Chen, Yingbo Lin, Qichun Zhou, Shilin Xiao, Chan Li, Rukun Lin, Jing Li, Yifei Chen, Chaohua Luo, Zhixian Mo
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Ginsenoside Rg1
Morphine
Gut microbiota
Tryptophan metabolism
5-HTR1B/5-HTR2A
Serotonin
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222003249

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http://www.sciencedirect.com/science/article/pii/S0753332222003249

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