Interleukin-6 modulates colonic transepithelial ion transport in the stress-sensitive Wistar Kyoto rat.

Immunological challenge stimulates secretion of the pro-inflammatory cytokine interleukin (IL)-6, resulting in variety of biological responses. In the gastrointestinal (GI) tract, IL-6 modulates the excitability of sub-mucosal neurons and stimulates secretion into the colonic lumen. When considered...

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Bibliographic Details
Main Authors: Dervla eO'Malley, Timothy eDinan, John F Cryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00190/full