Clozapine Suppresses the Gene Expression and the Production of Cytokines and Up-Regulates Cyclooxygenase 2 mRNA in Human Astroglial Cells

Clozapine Suppresses the Gene Expression and the Production of Cytokines and Up-Regulates Cyclooxygenase 2 mRNA in Human Astroglial Cells

Schizophrenia (SCZ) is a chronic neurodevelopmental psychotic disorder. The immune system and neuroinflammation seem to play a central role in the pathophysiology of SCZ. Clozapine is an effective atypical antipsychotic used for treatment-resistant SCZ. Life-threatening side effects, such as myocard...

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Bibliographic Details
Main Authors: Yael Yuhas, Shai Ashkenazi, Eva Berent, Abraham Weizman
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Brain Sciences
Subjects:
schizophrenia
neuroinflammation
clozapine
immune system
proinflammatory cytokines
TNFα
Online Access:https://www.mdpi.com/2076-3425/12/12/1703

Internet

https://www.mdpi.com/2076-3425/12/12/1703

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