Zebrafish as model system for the biological characterization of CK1 inhibitors

Zebrafish as model system for the biological characterization of CK1 inhibitors

Introduction: The CK1 family is involved in a variety of physiological processes by regulating different signaling pathways, including the Wnt/β-catenin, the Hedgehog and the p53 signaling pathways. Mutations or dysregulation of kinases in general and of CK1 in particular are known to promote the de...

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Bibliographic Details
Main Authors: Laura Meier, Bernd Martin Gahr, Aileen Roth, Adrian Gihring, Stefan Kirschner, Clemens Woitaske-Proske, Joana Baier, Christian Peifer, Steffen Just, Uwe Knippschild
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
CK1delta
CK1 specific small molecule inhibitors
zebrafish
CK1 orthologues
heart failure
blood stasis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1245246/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1245246/full

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