Novel Therapeutic Approaches Enhance PGC1-alpha to Reduce Oxidant Stress-Inflammatory Signaling and Improve Functional Recovery in Hibernating Myocardium

Novel Therapeutic Approaches Enhance PGC1-alpha to Reduce Oxidant Stress-Inflammatory Signaling and Improve Functional Recovery in Hibernating Myocardium

Ischemic heart disease affects millions of people around the world. Current treatment options, including coronary artery bypass grafting, do not result in full functional recovery, highlighting the need for novel adjunctive therapeutic approaches. Hibernation describes the myocardial response to pro...

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Bibliographic Details
Main Authors: Rishav Aggarwal, Koray N. Potel, Edward O. McFalls, Tammy A. Butterick, Rosemary F. Kelly
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antioxidants
Subjects:
PGC1-alpha
oxidative stress
NF-κB
hibernating myocardium
mitochondrial metabolism
mesenchymal stem cell
Online Access:https://www.mdpi.com/2076-3921/11/11/2155

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https://www.mdpi.com/2076-3921/11/11/2155

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