Potential interactions between metal-based phenanthroline drugs and the unfolded protein response endoplasmic reticulum stress pathway

The unfolded protein response has recently been implicated as a mechanism by which 1,10-phenanthroline-containing coordination compounds trigger cell death. We explored the interaction of two such compounds—one containing copper and one containing manganese—with endoplasmic reticulum (ER) stress. Pr...

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Bibliographic Details
Main Authors: Tadhg O’Leary, Pauraic McCarron, Michael Devereux, Steve Meaney, Eray Metin Guler
Format: Article
Language:English
Published: Cambridge University Press 2022-01-01
Series:Experimental Results
Subjects:
Online Access:https://www.cambridge.org/core/product/identifier/S2516712X2200020X/type/journal_article