The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice.

The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice.

High density lipoprotein (HDL) cholesterol levels are inversely related to cardiovascular disease risk and associated with a reduced risk of type 2 diabetes. Apolipoprotein A-I (apoA-I; major HDL protein) mimetics have been reported to reduce atherosclerosis and decrease adiposity. This study invest...

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Bibliographic Details
Main Authors: Michelle M Averill, Eung Ju Kim, Leela Goodspeed, Shari Wang, Savitha Subramanian, Laura J Den Hartigh, Chongren Tang, Yilei Ding, Catherine A Reardon, Godfrey S Getz, Alan Chait
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4186861?pdf=render

Internet

http://europepmc.org/articles/PMC4186861?pdf=render

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