Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement

Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement

Summary: DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide “snapshot” of >450,000 observations (probe measurements) per assay. However, the reliability of...

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Bibliographic Details
Main Authors: Karen Sugden, Eilis J. Hannon, Louise Arseneault, Daniel W. Belsky, David L. Corcoran, Helen L. Fisher, Renate M. Houts, Radhika Kandaswamy, Terrie E. Moffitt, Richie Poulton, Joseph A. Prinz, Line J.H. Rasmussen, Benjamin S. Williams, Chloe C.Y. Wong, Jonathan Mill, Avshalom Caspi
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Patterns
Subjects:
DNA methylation
epigenesis
genetic
epigenomics
reliability
reproducibility of results
Online Access:http://www.sciencedirect.com/science/article/pii/S2666389920300143

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http://www.sciencedirect.com/science/article/pii/S2666389920300143

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