Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of anesthetics. We report here the discovery of a no...

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Bibliographic Details
Main Authors: Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D Clark, Scott Runyon
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceuticals
Subjects:
neuropeptide S
antagonist
anxiolytic
NPSR
Online Access:https://www.mdpi.com/1424-8247/14/10/1024

Internet

https://www.mdpi.com/1424-8247/14/10/1024

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