Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma

Objective: The current obesity pandemic represents a major health burden, given that it predisposes to the development of numerous obesity-associated disorders. The obesity-derived adipokines not only impair systemic insulin action but also increase the incidence of hepatocellular carcinoma (HCC), a...

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Bibliographic Details
Main Authors: Melanie J. Mittenbühler, Hans-Georg Sprenger, Sabine Gruber, Claudia M. Wunderlich, Lara Kern, Jens C. Brüning, F. Thomas Wunderlich
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818306781