Immunogenicity and protective efficacy of recombinant Bacille Calmette-Guerin strains expressing mycobacterium antigens Ag85A, CFP10, ESAT-6, GM-CSF and IL-12p70

Immunogenicity and protective efficacy of recombinant Bacille Calmette-Guerin strains expressing mycobacterium antigens Ag85A, CFP10, ESAT-6, GM-CSF and IL-12p70

Objective: This study aimed to evaluate the immunogenicity and protective efficacy of recombinant bacille calmette-guerin (rBCG) strains expressing Ag85A (A), CFP10 (C), ESAT6 (E), IL-12p70 (I), and fusion protein GM-CSF (G). Method: rBCGs were established by integrating of A, C, E, I, G, AE, CE, IE...

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Bibliographic Details
Main Authors: Fu-Ying Dai, Jun-Fang Wang, Xue-Li Gong, Lang Bao
Format: Article
Language:English
Published: Taylor & Francis Group 2017-06-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
immunogenicity
protective efficacy
recombinant bacille calmette-guerin
tuberculosis
Online Access:http://dx.doi.org/10.1080/21645515.2017.1279771

Internet

http://dx.doi.org/10.1080/21645515.2017.1279771

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