Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination immunotherapy. Herein, a kind of tumor cascade-targeted responsive liposome (NLG919@Lip-pep1) is developed by conjugating polypeptide inhibitor of PD-1 signal pathway (AUNP-12), which...

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Bibliographic Details
Main Authors: Chuan Hu, Yujun Song, Yiwei Zhang, Siqin He, Xueying Liu, Xiaotong Yang, Tao Gong, Yuan Huang, Huile Gao
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Immunotherapy
Cascade targeting
Liposome
MMP-2 responsive
Breast cancer
ICBs
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523000564

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http://www.sciencedirect.com/science/article/pii/S2211383523000564

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