β-Hydroxybutyrate impairs the release of bovine neutrophil extracellular traps through inhibiting phosphoinositide 3-kinase–mediated nicotinamide adenine dinucleotide phosphate oxidase reactive oxygen species production

β-Hydroxybutyrate impairs the release of bovine neutrophil extracellular traps through inhibiting phosphoinositide 3-kinase–mediated nicotinamide adenine dinucleotide phosphate oxidase reactive oxygen species production

ABSTRACT: Ketosis in dairy cows often occurs in the peripartal period and is accompanied by immune dysfunction. High concentrations of β-hydroxybutyrate (BHB) in peripheral blood during ketosis inhibits the release of neutrophil extracellular traps (NET) and contributes to immune dysfunction. Howeve...

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Bibliographic Details
Main Authors: Siyuan Liu, Xiaobing Li, Xiaohan Zhou, Juan J. Loor, Qianming Jiang, Xiancheng Feng, Yuchen Yang, Lin Lei, Xiliang Du, Xinwei Li, Wang Zhe, Yuxiang Song, Guowen Liu
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Journal of Dairy Science
Subjects:
ketosis
neutrophil extracellular trap
nicotinamide adenine dinucleotide phosphate
reactive oxygen species
phosphoinositide 3-kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030222000595

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http://www.sciencedirect.com/science/article/pii/S0022030222000595

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