Intracellular Fate of the Photosensitizer Chlorin e4 with Different Carriers and Induced Metabolic Changes Studied by <sup>1</sup>H NMR Spectroscopy

Intracellular Fate of the Photosensitizer Chlorin e4 with Different Carriers and Induced Metabolic Changes Studied by <sup>1</sup>H NMR Spectroscopy

Porphyrinic photosensitizers (PSs) and their nano-sized polymer-based carrier systems are required to exhibit low dark toxicity, avoid side effects, and ensure high in vivo tolerability. Yet, little is known about the intracellular fate of PSs during the dark incubation period and how it is affected...

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Bibliographic Details
Main Authors: Martina Vermathen, Tobias Kämpfer, Jean-Marc Nuoffer, Peter Vermathen
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
photodynamic therapy
photosensitizer
porphyrinic compounds
polymeric carriers
nanoparticles
metabolic profile
Online Access:https://www.mdpi.com/1999-4923/15/9/2324

Internet

https://www.mdpi.com/1999-4923/15/9/2324

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