Nephrotoxic Potential of Putative 3,5-Dichloroaniline (3,5-DCA) Metabolites and Biotransformation of 3,5-DCA in Isolated Kidney Cells from Fischer 344 Rats

Nephrotoxic Potential of Putative 3,5-Dichloroaniline (3,5-DCA) Metabolites and Biotransformation of 3,5-DCA in Isolated Kidney Cells from Fischer 344 Rats

The current study was designed to explore the in vitro nephrotoxic potential of four 3,5-dichloroaniline (3,5-DCA) metabolites (3,5-dichloroacetanilide, 3,5-DCAA; 3,5-dichlorophenylhydroxylamine, 3,5-DCPHA; 2-amino-4,6-dichlorophenol, 2-A-4,6-DCP; 3,5-dichloronitrobenzene, 3,5-DCNB) and to determine...

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Bibliographic Details
Main Authors: Gary O. Rankin, Christopher R. Racine, Monica A. Valentovic, Dianne K. Anestis
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
nephrotoxicity
in vitro
rat
3,5-dichloroaniline
3,5-dichlorophenylhydroxylamine
3,5-dichloroacetanilide
Online Access:https://www.mdpi.com/1422-0067/22/1/292

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https://www.mdpi.com/1422-0067/22/1/292

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