PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy

PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy

Abstract IL-10+ regulatory B cells (Bregs) play a significant role in cancer immunotherapy and their presence is an indicator of negative outcome. We found that PPARδ is significantly upregulated in tumor-induced IL-10+ Bregs with a phenotype of CD19+CD24hiIgDlo/−CD38lo or CD19+CD24hiIgDlo/−CD38hi i...

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Bibliographic Details
Main Authors: Chen Chen, Jianan Ma, Chenchen Pi, Wei Huang, Tao Zhang, Cong Fu, Wentao Liu, Yong-Guang Yang
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00568-6

Internet

https://doi.org/10.1038/s41421-023-00568-6

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