Erythropoietin <i>N</i>-glycosylation of Therapeutic Formulations Quantified and Characterized: An Interlab Comparability Study of High-Throughput Methods

Erythropoietin <i>N</i>-glycosylation of Therapeutic Formulations Quantified and Characterized: An Interlab Comparability Study of High-Throughput Methods

Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome. EPO <i>N</i>-glycosylation influences important pharmacological parameters, prominently serum half-life. Ther...

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Bibliographic Details
Main Authors: Róisín O’Flaherty, Manuela Amez Martín, Richard A. Gardner, Patrick M. Jennings, Pauline M. Rudd, Daniel I. R. Spencer, David Falck
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomolecules
Subjects:
erythropoietin
EPO glycosylation
<i>N</i>-glycans
hydrophilic interaction chromatography
mass spectrometry
interlaboratory study
Online Access:https://www.mdpi.com/2218-273X/14/1/125

Internet

https://www.mdpi.com/2218-273X/14/1/125

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