Inclusion of site-specific mutations in the PB1-gene of a virulent A/WSN/33 (H1N1) strain of influenza A virus changes its phenotypic characteristics

Inclusion of site-specific mutations in the PB1-gene of a virulent A/WSN/33 (H1N1) strain of influenza A virus changes its phenotypic characteristics

Aim. Study of changes in the phenotypic characteristics of the virulent A/WSN/33 (H1N1) strain of influenza A virus under the influence of the inclusion of site-specific mutations in the PB1-gene of this strain.Materials and methods. Using a two-step polymerase reaction in the PB1 gene of A/ WSN/33...

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Bibliographic Details
Main Authors: V. Yu. Kost, O. A. Sukhova, I. I. Akopova, E. O. Gorbacheva, K. V. Lisovskaya, A. A. Rtishchev, S. G. Markushin
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2019-12-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
Subjects:
influenza virus
cold-adapted (ca) strains-donors of attenuation
site-specific mutagenesis
ts- phenotype
att-phenotype
immunogenicity
Online Access:https://microbiol.elpub.ru/jour/article/view/491

Internet

https://microbiol.elpub.ru/jour/article/view/491

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