Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts

Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts

Background: Glioblastoma multiforme (GBM) and metastatic triple-negative breast cancer (TNBC) with <i>PTEN</i> mutations often lead to brain dissemination with poor patient outcome, thus new therapeutic targets are needed. To understand signaling, controlling the dynamics and mechanics o...

Full description

Bibliographic Details
Main Authors: Annalena Wieland, Pamela L. Strissel, Hannah Schorle, Ezgi Bakirci, Dieter Janzen, Matthias W. Beckmann, Markus Eckstein, Paul D. Dalton, Reiner Strick
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
3D tumor model
3D microfiber
amoeboid cell migration
brain cancer
breast cancer
PTEN
Online Access:https://www.mdpi.com/2072-6694/13/20/5144

Internet

https://www.mdpi.com/2072-6694/13/20/5144

Similar Items