RNA-Seq of Dermal Fibroblasts from Patients with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Supports Their Categorization as a Single Entity with Involvement of Extracellular Matrix Degrading and Proinflammatory Pathomechanisms

RNA-Seq of Dermal Fibroblasts from Patients with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorders Supports Their Categorization as a Single Entity with Involvement of Extracellular Matrix Degrading and Proinflammatory Pathomechanisms

Hypermobile Ehlers–Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are clinically overlapping connective tissue disorders of unknown etiology and without any validated diagnostic biomarker and specific therapies. Herein, we in-depth characterized the cellular phenotype and gene exp...

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Bibliographic Details
Main Authors: Marco Ritelli, Nicola Chiarelli, Valeria Cinquina, Nicoletta Zoppi, Valeria Bertini, Marina Venturini, Marina Colombi
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
cytokines
extracellular matrix
hypermobile Ehlers–Danlos syndrome
hypermobility spectrum disorders
inflammation
matrix metalloproteinases
Online Access:https://www.mdpi.com/2073-4409/11/24/4040

Internet

https://www.mdpi.com/2073-4409/11/24/4040

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