Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. SE50/110

Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. SE50/110

Actinoplanes sp. SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. Although maltose is an important building block of acarbose, the maltose/maltodextrin metabol...

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Bibliographic Details
Main Authors: Lena Schaffert, Susanne Schneiker-Bekel, Saskia Dymek, Julian Droste, Marcus Persicke, Tobias Busche, David Brandt, Alfred Pühler, Jörn Kalinowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Microbiology
Subjects:
PurR/LacI-type transcriptional regulator
maltase MalL
amlE-amlR gene arrangement
acb and gac gene cluster
maltose/maltodextrin metabolism
hydrolase assay
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02448/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02448/full

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