Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples

In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in total human plasma.

Bibliographic Details
Main Authors: Guinevere S. M. Lageveen-Kammeijer, Noortje de Haan, Pablo Mohaupt, Sander Wagt, Mike Filius, Jan Nouta, David Falck, Manfred Wuhrer
Format: Article
Language:English
Published: Nature Portfolio 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09910-7