Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study, three series of novel polysubstituted N-alkyl acridone analogous were designed and synthesised as HDAC isoform-selective inhibitors. Among them, 11b and 11c exhibited selective inhibition of HDAC1, HDAC3, an...

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Bibliographic Details
Main Authors: Ze Wang, Li Zhao, Bo Zhang, Jiahe Feng, Yule Wang, Bin Zhang, Haixiao Jin, Lijian Ding, Ning Wang, Shan He
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Design and synthesis
hit compound
anticancer
histone deacetylases
isoform-selective inhibitors
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2206581

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2206581

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