Development and Validation of a Highly Sensitive and Rapid LC-MS<sup>3</sup> Strategy to Determine Oxcarbazepine and Its Active Metabolite in the Serum of Patients with Epilepsy and Its Application in Therapeutic Drug Monitoring

Development and Validation of a Highly Sensitive and Rapid LC-MS<sup>3</sup> Strategy to Determine Oxcarbazepine and Its Active Metabolite in the Serum of Patients with Epilepsy and Its Application in Therapeutic Drug Monitoring

A sensitive and rapid bioanalytical method based on the LC-triple-stage fragmentation (LC-MS<sup>3</sup>) strategy on a hybrid triple quadrupole-linear ion trap mass spectrometer in combination with protein precipitation extraction for sample pretreatment has been developed and validated...

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Bibliographic Details
Main Authors: Zhengchao Ji, Tingting Li, Xin Zhao, Wei Ma, Yanyan Li, Jing Huang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
oxcarbazepine
10-hydroxycarbazepine
LC-MS<sup>3</sup>
validation
therapeutic drug monitoring
Online Access:https://www.mdpi.com/1420-3049/27/17/5670

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https://www.mdpi.com/1420-3049/27/17/5670

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