Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

GluN1 is a mandatory component of N-methyl-D-aspartate receptors (NMDARs) best known for their roles in the brain, but with increasing evidence for relevance in peripheral tissues, including platelets. Certain anti-GluN1 antibodies reduce brain infarcts in rodent models of ischaemic stroke. There is...

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Bibliographic Details
Main Authors: Taryn N. Green, Justin R. Hamilton, Marie-Christine Morel-Kopp, Zhaohua Zheng, Ting-Yu T. Chen, James I. Hearn, Peng P. Sun, Jack U. Flanagan, Deborah Young, P. Alan Barber, Matthew J. During, Christopher M. Ward, Maggie L. Kalev-Zylinska
Format: Article
Language:English
Published: Taylor & Francis Group 2017-11-01
Series:Platelets
Subjects:
calcium
glutamate
ion channel
platelet inhibitor
stroke
Online Access:http://dx.doi.org/10.1080/09537104.2017.1280149

Internet

http://dx.doi.org/10.1080/09537104.2017.1280149

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