Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury

Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury

BackgroundNeuroinflammation following spinal cord injury (SCI) results in prolonged neurological damage and locomotor dysfunction. Polarization of microglia is vital to regulation of neuroinflammation, although the underlying mechanisms have not yet been elucidated. Endocannabinoid receptor subtype...

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Bibliographic Details
Main Authors: Fan Jiang, Mingjie Xia, Yanan Zhang, Jie Chang, Jiang Cao, Zhongkai Zhang, Zhanyang Qian, Lei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
cannabinoid receptor-2
neuroinflammation
NLRP3
autophagy
spinal cord injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.993168/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.993168/full

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