A T cell redirection platform for co-targeting dual antigens on solid tumors

A T cell redirection platform for co-targeting dual antigens on solid tumors

In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell Engager (DATE), by fusing a single-chain variable fragment targeting CD3 to a tumor-targeting antigen-binding fragment. In this format, multiple novel paratope...

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Bibliographic Details
Main Authors: Leonie Enderle, Karim H. Shalaby, Maryna Gorelik, Alexander Weiss, Levi L. Blazer, Marcin Paduch, Lia Cardarelli, Anthony Kossiakoff, Jarrett J. Adams, Sachdev S. Sidhu
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
Antibody/immunotherapy/pancreatic cancer/solid tumors/T-cell redirection/CD133/EPHA2/EPCAM/EPHB2/dual targeting
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.1933690

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2021.1933690

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