Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers

Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers

Abstract Background Proteins of the TGFβ family, which are largely studied as homodimers, are also known to form heterodimers with biological activity distinct from their component homodimers. For instance, heterodimers of bone morphogenetic proteins, including BMP2/BMP7, BMP2/BMP6, and BMP9/BMP10,...

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Main Authors: Gregory R. Gipson, Kristof Nolan, Chandramohan Kattamuri, Alan P. Kenny, Zachary Agricola, Nicole A. Edwards, Joseph Zinski, Magdalena Czepnik, Mary C. Mullins, Aaron M. Zorn, Thomas B. Thompson
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Biology
Subjects:
BMP
Growth factor
Heterodimer
Cell signaling
Online Access:https://doi.org/10.1186/s12915-023-01522-4

Internet

https://doi.org/10.1186/s12915-023-01522-4

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