Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer

Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer

Summary: Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer, with a 10% five-year survival rate. However, little is known about its origin and the mechanisms governing its emergence. Our study characterized ADPC and NEPC in prostate tumors from 7 patients using scRNA-seq. F...

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Bibliographic Details
Main Authors: Ziwei Wang, Tao Wang, Danni Hong, Baijun Dong, Yan Wang, Huaqiang Huang, Wenhui Zhang, Bijun Lian, Boyao Ji, Haoqing Shi, Min Qu, Xu Gao, Daofeng Li, Colin Collins, Gonghong Wei, Chuanliang Xu, Hyung Joo Lee, Jialiang Huang, Jing Li
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
Subjects:
Cancer systems biology
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222008483

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http://www.sciencedirect.com/science/article/pii/S2589004222008483

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