Amantadine and/or transcranial magnetic stimulation for fatigue associated with multiple sclerosis (FETEM): study protocol for a phase 3 randomised, double-blind, cross-over, controlled clinical trial

Amantadine and/or transcranial magnetic stimulation for fatigue associated with multiple sclerosis (FETEM): study protocol for a phase 3 randomised, double-blind, cross-over, controlled clinical trial

Introduction Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), and effective treatments are lacking. Amantadine is one of the most used treatments, although its efficacy is under debate. Transcranial magnetic stimulation (TMS) is a promising intervention that has shown positi...

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Bibliographic Details
Main Authors: Antonio Portoles, Julián Benito-León, Jordi A Matias-Guiu, Jorge Matias-Guiu, Julio Prieto, Javier González-Rosa, Miguel Ángel Hernández, Maria Luisa Martínez-Ginés, Natalia Pérez-Macías, Iván Padrón
Format: Article
Language:English
Published: BMJ Publishing Group 2024-01-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/1/e078661.full

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https://bmjopen.bmj.com/content/14/1/e078661.full

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